With a female actor and cabaret theatre operator, the exhibitionist mother of an uptight hotel porter, the mentally unstable sister of a director who is unable to work due to high blood pressure, who seduces two young Jehovah's Witnesses, and more.

In terms of urban history, "Damned to all Vanity" is significant because it was largely filmed in the legendary Hotel Bogota (with the former studio of photographer Yva) in Charlottenburg's Schlüterstraße.